|Statement||A.G. Johnston ; supervised by D.A. Leigh..|
|Contributions||Leigh, D. A., Chemistry.|
Molecules, an international, peer-reviewed Open Access journal. Dear Colleagues, The last two decades have witnessed major breakthroughs in the identification of genes, gene products, metabolic pathways, and signalling pathways, as well as progress in miniaturization and robotics, enabling the development of high-throughput mechanism-based biological assays. A hot topic is the design of selective sensors for Hg 2+, one of the most hazardous pollutants of the environment. In this context, a new tren-based starburst molecule containing fluorinated 1,2,4-oxadiazoles as fluorophores has been synthesized and its sensing behavior towards several metal cations has been investigated by UV/Vis, fluorescence. G proteins are stimulated by cell surface receptors (GPCR) that catalyze the exchange of GDP, bound to Gα subunit, with GTP and can per se be the target of drugs. Based on the structure of two nonpeptidic modulators of Gi proteins, a series of new molecules characterized by a long hydrophobic chain and at least two nitrogen atoms protonated at. The topics of this Special Issue cover drug design, molecular modeling and synthesis, structure–activity relationships on ligands with distinct properties (agonists, antagonists, partial agonists, biased agonists, allosteric modulators and ligands acting at multiple opioid receptors) or selective site of action (central, peripheral), drug.
Chemosensors function on a molecular level, generating a signal upon binding. The book reviews their synthesis, design, and applications for detecting biological and organic molecules as well as metal ions. Discusses the design of sensors for small molecules for which biotic receptors have not evolved or are not readily adapted for sensing. Vinylstannylated alkylating agents as prosthetic groups for radioiodination of small molecules: design, synthesis, and application to iodoallyl analogs of spiperone and diprenorphine novel ligands designed for imaging studies of peripheral opioid receptors. Shefali Srivastava, Emily A. Fergason-Cantrell a truncated approach to molecular Cited by: Abstract. Artificial receptors have been employed in molecular recognition for a variety of biological applications. They have been used as materials for sensors, affinity separation, solid-phase extraction, and for research into biomolecular by: A molecular sensor or chemosensor is a molecular structure (organic or inorganic complexes) that is used for sensing of an analyte to produce a detectable change or a signal. The action of a chemosensor, relies on an interaction occurring at the molecular level, usually involves the continuous monitoring of the activity of a chemical species in a given matrix such as solution, .
The design strategy for the development of small molecular FRET sensors is described in terms of avoiding close contact of donor fluorophore and acceptor fluorophore in aqueous : Kazuya Kikuchi. Design, Synthesis and Evaluation of Small Molecule Hsp90 Probes. a number of oncogenic proteins critically depend on the Hsp90 molecular chaperone to obtain an . The design of small molecule fluorescent sensors is currently a popular research field, which stands to contribute much to the understanding of biological systems. However, it is essential that efforts be better directed, to maximize the utility of such systems. This Sensor Issues article discusses the current challenges and opportunities in the field, highlighting the need for better. Chemosensors function on a molecular level, generating a signal upon binding. The book reviews their synthesis, design, and applications for detecting biological and organic molecules as well as metal ions. The text highlights applications in drug discovery and catalyses that have not been well covered elsewhere.